BCL2A1 polyclonal antibody
产品名称： BCL2A1 polyclonal antibody
英文名称： BCL2A1 polyclonal antibody
产品编号： PAB13211
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BCL2A1.
- Immunogen:
- A synthetic peptide corresponding to C-terminus 14 amino acids of human BCL2A1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Up-regulation of Bfl-1/A1 via NF-kappaB activation in cisplatin-resistant human bladder cancer cell line.
Kim JK, Kim KD, Lee E, Lim JS, Cho HJ, Yoon HK, Cho MY, Baek KE, Park YP, Paik SG, Choe YK, Lee HG.Cancer Lett. 2004 Aug 20;212(1):61-70.
- 2.
- Cell death in the third millennium.
Lockshin RA, Osborne B, Zakeri Z.Cell Death Differ. 2000 Jan;7(1):2-7.
- 3.
- A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.
Choi SS, Park IC, Yun JW, Sung YC, Hong SI, Shin HS.Oncogene. 1995 Nov 2;11(9):1693-8.
- Entrez GeneID:
- 597
- Protein Accession#:
- NP_004040
- Gene Name:
- BCL2A1
- Gene Alias:
- ACC-1,ACC-2,BCL2L5,BFL1,GRS,HBPA1
- Gene Description:
- BCL2-related protein A1
- Omim ID:
- 601056
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- hematopoietic BCL2-related protein A1
- Gene Pathway
- Related Disease
- Cardiovascular Diseases
- Dermatitis, Atopic
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Graft vs Host Disease
- Hematologic Diseases
- Hodgkin Disease
- Kidney Failure, Chronic
- Lymphoma, B-Cell
- Lymphoma, Follicular
- Lymphoma, Large B-Cell, Diffuse
- Lymphoproliferative Disorders
- Occupational Diseases
- Waldenstrom Macroglobulinemia
- Werner syndrome