Phorbol 12-myristate 13 acetate
PMA
Catalog No: KC-4P003
Size: 1 mgPhysical Appearance: Colorless oil
Molecular Formula: C36H56O8
Molecular Weight: 616.8
Purity: 99% (TLC)
Solubility: Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
Storage: Store, as supplied, at –20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Description: Extremely potent mouse skin tumor promoter. Activates protein kinase C (PKC) in vivo and in vitro, even at nanomolar concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Most commonly used phorbol ester.
References:
1. M.Castagna et al. J.Biol.Chem. 1982 257 7847
2. W.J.Ryves et al. FEBS Lett. 1991 288 5
CAUTION!!! The pharmacological and toxicological properties of this product have not been fully investigated. Avoid all forms of contact with this product by wearing appropriate protective clothing (gloves, mask, and lab coat). The Material Safety Data Sheet (MSDS), is available on request. This product must not be used in humans